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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
23.03
Human Site:
Y625
Identified Species:
50.67
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
Y625
E
E
R
C
C
F
L
Y
V
L
H
N
S
D
D
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
Y626
E
E
R
C
C
F
L
Y
V
L
H
N
S
D
D
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
L594
R
C
C
F
L
Y
A
L
P
P
A
Q
D
V
Q
Dog
Lupus familis
XP_533420
1645
181128
Y896
E
E
R
C
C
F
L
Y
V
L
H
N
S
D
D
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
Y632
E
E
R
C
C
F
L
Y
V
L
H
N
S
D
D
Rat
Rattus norvegicus
XP_001073260
1338
150427
Y596
E
E
R
C
C
F
L
Y
V
L
H
N
S
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
G566
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
Chicken
Gallus gallus
XP_419725
1260
143069
G567
D
Y
E
Y
D
E
N
G
E
R
V
V
L
G
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
Y614
D
E
R
S
C
F
L
Y
V
V
N
N
S
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
V567
T
A
D
Q
V
V
F
V
N
L
S
N
D
D
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
T586
N
E
I
E
Y
E
F
T
E
S
K
D
R
V
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
0
0
N.A.
66.6
N.A.
20
N.A.
N.A.
6.6
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
20
6.6
N.A.
93.3
N.A.
20
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
19
0
0
0
10
0
0
0
10
% A
% Cys:
0
10
10
46
55
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
19
0
10
0
10
0
0
0
0
10
0
10
19
55
55
% D
% Glu:
46
64
10
10
0
19
0
0
19
0
0
0
0
10
0
% E
% Phe:
0
0
0
10
0
55
19
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
0
19
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
46
0
0
0
0
% H
% Ile:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% K
% Leu:
0
0
0
0
10
0
55
10
0
55
10
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% M
% Asn:
10
0
0
0
0
0
10
0
10
0
10
64
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
0
0
0
0
0
0
10
0
10
10
% Q
% Arg:
10
0
55
0
0
0
0
0
10
10
0
0
10
0
0
% R
% Ser:
0
0
0
10
0
0
0
0
0
10
10
10
55
0
0
% S
% Thr:
19
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
19
10
0
10
55
10
10
10
0
19
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
19
0
10
10
19
0
55
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _